Investigation of the Neogene and Quaternary geology of the Milford and Mispillion River quadrangles has identified six formations: the Calvert, Choptank, and St. Marys formations of the Chesapeake Group, the Columbia Formation, and the Lynch Heights and Scotts Comers formations of the Delaware Bay Group. Stream, swamp, marsh, shoreline, and estuarine and bay deposits of Holocene age are also recognized. The Calvert, Choptank, and St. Marys formations were deposited in inner shelf marine environments during the early to late Miocene. The Columbia Formation is of fluvial origin and was deposited during the middle Pleistocene prior to the erosion and deposition associated with the formation of the Lynch Heights Formation. The Lynch Heights Formation is of fluvial and estuarine origin and is of middle Pleistocene age. The Scotts Corners Formation was deposited in tidal, nearshore, and estuarine environments and is of late Pleistocene age. The Scotts Corners Formation and the Lynch Heights Formation are each interpreted to have been deposited during more than one cycle of sea-level rise and fall. Latest Pleistocene and Holocene deposition has occurred over the last 11,000 years.