Data from three streamflow water-quality stations were statistically analyzed to determine the relationships of the major inorganic chemical constituents to specific conductance and to stream discharge. The results show that ion concentrations varied directly with the flow and with specific conductance. A set of regression equations defining these relationships were derived for each of the three stations: Brandywine Creek at Wilmington, St. Jones River at Dover, and Nanticoke River near Bridgeville.